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AJPH Releases New Influenza Articles From Experts On Vulnerable Populations Early
In light of interest in the ongoing H1N1 influenza outbreak, several scientific papers are being published online ahead of schedule. A special supplement to the American Journal of Public Health (AJPH) on influenza preparedness, in which these and other papers appear, will be published as scheduled later this year.
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Mapping Gene Expression With Gene Expression Atlas
Recently, researchers at the European Molecular Biology Laboratory"s European Bioinformatics Institute (EMBL-EBI) launched a new database, the Gene Expression Atlas, which allows scientists to search and compare gene expression data at unprecedented detail and scope. Observing how gene expression varies in different cell types, tissues and under disease conditions can help researchers understand gene function and to develop new drugs and therapies.
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San Diego Needle Exchange Program Examined
KPBS profiled San Diego"s "only clean syringe exchange program," a mobile van that twice weekly provides injection drug users with clean needles in exchange for used ones. The program also offers HIV and Hepatitis C tests and gives referrals to drug treatment programs. According to KPBS, "The concept behind syringe exchange is simple: people are going to shoot drugs. It"s crucial to make sure they have access to clean equipment, so they don"t spread blood-borne infections." However, the San Diego County Board of Supervisors is "adamantly opposed to the concept," and it is "illegal in San Diego for people to buy clean needles without a prescription," KPBS reports. In 2008, the privately-funded exchange program, which has the support of the mayor and the city council, collected more than 183,000 used syringes and handed out about 172,000 new ones (Goldberg, 7/7).
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Working Towards An Optical Integrated Circuit

ETH Zurich researchers have successfully created an optical transistor from a single molecule. This has brought them one step closer to an optical computer. Internet connections and computers need to be ever faster and more powerful nowadays. However, conventional central processing units (CPUs) limit the performance of computers, for example because they produce an enormous amount of heat. The millions of transistors that switch and amplify the electronic signals in the CPUs are responsible for this. One square centimeter of CPU can emit up to 125 watts of heat, which is more than ten times as much as a square centimeter of an electric hotplate. Photons instead of electrons This is why scientists have been trying for some time to find ways to produce integrated circuits that operate on the basis of photons instead of electrons. The reason is that photons do not only generate much less heat than electrons, but they also enable considerably higher data transfer rates. Although a large part of telecommunications engineering nowadays is based on optical signal transmission, the necessary encoding of the information is generated using electronically controlled switches. A compact optical transistor is still a long way off. Vahid Sandoghdar, Professor at the Laboratory of Physical Chemistry of ETH Zurich, explains that, "Comparing the current state of this technology with that of electronics, we are somewhat closer to the vacuum tube amplifiers that were around in the fifties than we are to today"s integrated circuits." However, his research group has now achieved a decisive breakthrough by successfully creating an optical transistor with a single molecule. For this, they have made use of the fact that a molecule"s energy is quantized: when laser light strikes a molecule that is in its ground state, the light is absorbed. As a result, the laser beam is quenched. Conversely, it is possible to release the absorbed energy again in a targeted way with a second light beam. This occurs because the beam changes the molecule"s quantum state, with the result that the light beam is amplified. This so-called stimulated emission, which Albert Einstein described over 90 years ago, also forms the basis for the principle of the laser. Focusing on a nano scale Jaesuk Hwang, first author of the study and a scientific member of Sandoghdar"s nano-optics group, explains that, "Amplification in a conventional laser is achieved by an enormous number of molecules." By focusing a laser beam on only a single tiny molecule, the ETH Zurich scientists have now been able to generate stimulated emission using just one molecule. They were helped in this by the fact that, at low temperatures, molecules seem to increase their apparent surface area for interaction with light . The researchers therefore needed to cool the molecule down to minus 272 degrees Celsius (minus 457.6 degrees Fahrenheit), i.e. one degree above absolute zero. In this case, the enlarged surface area corresponded approximately to the diameter of the focused laser beam. Switching light with light By using one laser beam to prepare the quantum state of a single molecule in a controlled fashion, scientists could significantly attenuate or amplify a second laser beam. This mode of operation is identical to that of a conventional transistor, in which electrical potential can be used to modulate a second signal. Thus component parts such as the new single molecule transistor may also pave the way for a quantum computer. Sandoghdar says, "Many more years of research will still be needed before photons replace electrons in transistors. In the meantime, scientists will learn to manipulate and control quantum systems in a targeted way, moving them closer to the dream of a quantum computer." Reference: J. Hwang, M. Pototschnig, R. Lettow, G. Zumofen, A. Renn, S. Gç¶tzinger, V. Sandoghda: A single-molecule opzical transistor, Nature (2009) 460, 76-80,doi:10.1038/nature08134 ETH Zuerich


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