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Maternal Immunity Not All Good For A Fetus
As a fetus does not mount an immune response to maternal proteins that cross the placenta, it has been assumed that a fetus would not reject non-genetically matched blood cells (specifically allogeneic blood cells) if they were transplanted while the fetus was in utero. The hope is that this procedure, which is known as IUHCT, could provide a viable approach for treating congenital blood disorders. However, studies using a mouse model of IUHCT indicate that most fetal recipients of allogeneic blood cells lose their transplanted cells 3-5 weeks after transplantation. Alan Flake and colleagues, at Children"s Hospital of Philadelphia, have now identified an immune mechanism responsible for graft failure in this model of IUHCT. Surprisingly, although fetal immune cells eliminated the transplanted allogeneic blood cells, they were triggered to do so by immune molecules known as alloantibodies that they obtained from their mother"s breast milk. The maternal alloantibodies were produced in response to IUHCT and so the authors conclude that in the absence of either a maternal immune response or transmission of the maternal alloantibodies to the fetus, transplanted blood cells should not be rejected, leaving open the door for IUHCT as a potential clinical strategy.
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South Africa Launches HIV/AIDS Research Initiative
South Africa"s Science and Technology Minister Naledi Pandor on Tuesday announced a government-sponsored research initiative that "aims to combat HIV and AIDS through scientific and technological research, the development of new drugs, diagnostic tests and vaccines," SAPA/IOL reports (7/28). "[K]ey focus areas" of the South Africa HIV/AIDS Research and Innovation Platform (SHARP) will be prevention and therapeutics, according to BuaNews (7/28).
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FDA: Boxed Warning On Serious Mental Health Events To Be Required For Chantix And Zyban
The U.S. Food and Drug Administration announced that it is requiring manufacturers to put a Boxed Warning on the prescribing information for the smoking cessation drugs Chantix (varenicline) and Zyban (bupropion). The warning will highlight the risk of serious mental health events including changes in behavior, depressed mood, hostility, and suicidal thoughts when taking these drugs.
Mental Health

Successful Disease Management Programs Can Play Role In Health Care Reform

A study of the award-winning Behavioral Pharmacy Management Program (BPM) shows the private-public Medicaid partnership program has helped improve patient care while saving eight states almost $95 million in behavioral health pharmaceutical costs. Lilly funds the program, which is designed and run by research firm Comprehensive NeuroScience, Inc. (CNS) at the sole direction and guidance of state Medicaid departments. The BPM, which has been executed in more than half of the states, has won a variety of national awards, including the Substance Abuse and Mental Health Services Administration Science and Service Award, URAC Silver Award for Best Practices in Consumer Empowerment and Protection, American Psychiatric Association Bronze Achievement Award and Disease Management Association of America Gold Award. Missouri, one of the states included in the study, has seen significant improvements in patient care, as well as Medicaid cost savings. "We need to make sure we take the very best care of the Medicaid patients we serve and help them understand how to take the very best care of themselves. With the BPM, we have the opportunity to do that by simply targeting best practices and making educational information available to physicians, so they understand the best practice alternatives. We believe that, if you do the right things, the cost will follow and it has," said George Oestreich, deputy division director, Clinical Services, MO HealthNet Division. "Controlling health care costs and improving quality is a big, complicated issue. These kinds of partnerships, which pursue quality as a way to contain costs, are really going to be the solution to a lot of the health care problems that America faces," said Dr. Joseph Parks, chief clinical officer and division director, Comprehensive Psychiatric Services, Missouri Department of Mental Health. How the Program Works The BPM reviews Medicaid prescription patterns for more than 400 mental health medications. Then, it compares them to national best practice guidelines, which are compiled by each state Medicaid department and CNS. These guidelines are based on the latest medical research, including studies published in peer-reviewed medical journals. When there is an inconsistency with what is considered best prescribing practice, the BPM sends an educational mailing to the physician, so they can consider the information for the next visit with the patient. Some of the inconsistent patterns the program has identified include: duplicative prescribing of a medication by different doctors for the same patient; prescribing above or below recommended dosing levels; and prescribing multiple medications from the same therapeutic class. "Physicians will change their prescribing practice patterns to be in keeping with best practice, when they know what the best practice is. They use the educational information from the program"s mailing, and, when they do, the overall care of the patient is improved, and we see overall reduction in health care costs," said Carol D. Clayton, Ph.D., vice president, account management services, CNS. The BPM also informs physicians when their patient has not refilled their prescription. This is a health care concern because poor compliance or non-compliance with medication treatment is strongly is linked to relapse, rehospitalization, poor outcomes, and high economic costs. In addition, physicians receive regular information bulletins about special topics related to mental health medications, such as tips for addressing and discussing treatment adherence with patients. Eight-State Study Cost Savings Results The study, conducted by CNS, evaluated eight representative state BPMs to determine behavioral pharmacy costs for Medicaid patients whose physicians received an educational mailing compared to costs for a similar group of patients who had not yet been a subject of a mailing. On average, the program helped states avoid almost $800 in behavioral health pharmaceutical costs each year, per patient, or a total of $94.5 million since the programs began for the eight states studied. "These data document that it is possible to improve the care of people with psychiatric illness in a cost-efficient manner. The treatment of mental illness has advanced remarkably in recent years, but those advances are generally only slowly translated into better clinical practice. The BPM puts evidence-based best practice guidelines into clinicians" hands on a fast track," said Jack Gorman, MD, SVP and chief scientific officer, CNS. "The Behavioral Pharmacy Management Program is an excellent example of evidence-based interventions that increase access to quality mental health care while reducing costs. Community behavioral health providers across the nation are committed to replicating such science to service initiatives to provide outcomes that benefit individual patients," said Linda Rosenberg, MSW, president and CEO, National Council for Community Behavioral Healthcare. Patient Care Improvement Results In addition to saving Medicaid costs, the BPM has resulted in more than 2 million patient care improvements nationwide. For example, an analysis of the first year of Missouri"s BPM found a: - 98 percent decrease in the number of patients who are prescribed the same mental health medications from multiple doctors; - 64 percent decrease in the number of patients who are on two or more mental health medications of the same type; and - 40 percent decrease in the number of patients receiving an unusually high dosage of medication. A separate study of Missouri Medicaid patients found a 43 percent decrease in hospital admissions for those whose physicians received an educational mailing versus a 1 percent decrease in those from a similar comparison group who did not yet receive a mailing.6 For other state examples of patient care improvements and cost savings, visit http://www.lillyforbetterhealth.com. The program has run in 26 states, including Oklahoma, which began its BPM in 2004. "We call our BPM "SoonerPSYCH" which stands for Prescription Solutions for Your Cognitive Health. Through the program, our partnership with Lilly and CNS has allowed us to target physicians with patient-specific information and education in the most efficient and effective manner. Physicians are able to know whether their patients are filling the prescriptions on time or not at all, and to see if other physicians are prescribing similar medications for the same patient. Having the information in hand provides an opportunity for the physician to educate the patient about the chronic nature of their condition and the importance of persistence, compliance and adherence to their prescribed medication regimen," said Nancy Nesser, J.D., Pharm. D. pharmacy director for the Oklahoma Health Care Authority"s state SoonerCare program. Evidence suggests that 96 cents of every Medicare dollar and 83 cents of every Medicaid dollar are used to treat chronic diseases.7 Disease management programs help patients with chronic diseases manage their condition and get the care they need. For more than seven years, Lilly has funded disease management programs in partnership with state Medicaid departments. "Just like cancer or diabetes, mental illness is a devastating disease that impacts millions. We believe disease management and coordination of care programs that leverage health care information, technology and education are a viable option to manage rising health care costs rather than limiting patients" access to vital medications and treatments," said Alex M. Azar II, vice president of business-to-business, LillyUSA Lilly provides financial support for the initiative, with the operation and implementation of the program being done solely by the states and CNS. If the state decides to share data with Lilly, the data is blinded and aggregated and does not contain information about individual patients or providers. In addition, Lilly has sought approval and received support from the Centers for Medicare & Medicaid Services for these initiatives. The BPM is entirely voluntary for physicians. All decisions regarding treatment and medications are made privately between the physician and the patient and are completely individualized. Eli Lilly and Company


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