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Report On Contaminated Drinking Water At Camp Lejeune
Two chemicals - trichloroethylene (TCE) and tetrachloroethylene (PCE) - found to have contaminated drinking water at Marine Corps Base Camp Lejeune from the 1950s to 1985 have been linked to certain diseases and disorders, including various cancers. A new report from the National Research Council, Contaminated Water Supplies at Camp Lejeune - Assessing Potential Health Effects, reviews scientific evidence about the potential adverse health effects that could occur after exposure to TCE, PCE, and other contaminants; recommends the usefulness of conducting additional studies on former residents of the base; and identifies scientific considerations that could help the U.S. Department of the Navy, under which the Marine Corps operates, set priorities on future actions. The report will be released at a 90-minute public briefing.
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DrugScope Welcomes APHO Report On Drug Use In England
DrugScope has welcomed the publication of the Association of Public Health Observatories report into drug use in England.
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Lupus Drug Benlysta Effective In Phase 3 Trials
In what has been described as the first lupus drug in decades to show effectiveness in phase 3 clinical trials, the announcement that Benlysta
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Sleep And Weight Gain: A Molecular Link

There appears to be a link between sleep and weight control, with some studies indicating that sleep disruption can increase weight gain and others that diet affects sleep. Victor Uebele and colleagues, at Merck Research Laboratories, West Point, have now provided further evidence to support this association by showing that T-type calcium channels regulate body weight maintenance and sleep in mice. These data suggest that sleep and circadian treatment approaches may be of benefit in the fight against obesity. Previous studies have shown that mice lacking the CaV3.1 T-type calcium channel have disrupted sleep/wake activity. In this study, the researchers found that these mice were resistant to weight gain when fed a high-fat diet. Consistent with these data, when normal-weight rodents were administered a drug that specifically antagonized T-type calcium channels during their inactive phase they showed increased sleep and were protected from weight gain due to a high-fat diet. Further, when the same drug was given to obese rodents it reduced body weight and fat mass. The authors conclude that the benefits of the drug are likely to be a result of better alignment of feeding patterns and the circadian rhythm, and that targeting T-type calcium channels might provide a new avenue of research for those developing drugs to treat obesity. TITLE: Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice AUTHOR CONTACT: Victor N. Uebele Merck Research Laboratories, West Point, Pennsylvania, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=36954 Karen Honey Journal of Clinical Investigation


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