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Addex Partner Starts First-Ever Clinical Trial Of An MGluR Positive Allosteric Modulator
Allosteric modulation company Addex Pharmaceuticals (SWISS: ADXN) announced today that its partner Ortho-McNeil- Janssen Pharmaceuticals Inc. (OMP) has started Phase I testing of ADX71149, a metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM). This product, which has potential to treat schizophrenia, anxiety, depression and other CNS disorders, is the first PAM of any mGluR subtype to enter clinical trials. Targeting mGluR2 with a PAM is a novel approach that may offer advantages over classical drug approaches. In reaching this milestone, Addex received a EUR 1 million payment from OMP and remains eligible for additional development milestones and royalties.
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Follow-Up Study Further Reinforces The Long-Term Benefits Of Tight Glucose Control In Early Treatment Of Diabetes
A study published in today"s issue of the Archives of Internal Medicine provides further reinforcement that tight control of blood glucose as soon as possible after a diagnosis of type 1 diabetes yields long-term benefits with regard to lowering the rates of eye, kidney and heart complications associated with diabetes. These findings stem from the landmark Diabetes Control and Complications Trial (DCCT) and its follow-up study, the Epidemiology of Diabetes Interventions and Complications (EDIC), both funded by the National Institutes of Health.
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Call For Public Debates On Future Uses Of Stem Cells Lead By Bioethicists
More than 40 scientists, bioethicists, lawyers and science journal editors are calling on their colleagues, policy makers and the public to begin developing guidelines for the research and reproductive use of stem cell-derived eggs and sperm, even though such use may be a decade or more away.
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San Diego Needle Exchange Program Examined

KPBS profiled San Diego"s "only clean syringe exchange program," a mobile van that twice weekly provides injection drug users with clean needles in exchange for used ones. The program also offers HIV and Hepatitis C tests and gives referrals to drug treatment programs. According to KPBS, "The concept behind syringe exchange is simple: people are going to shoot drugs. It"s crucial to make sure they have access to clean equipment, so they don"t spread blood-borne infections." However, the San Diego County Board of Supervisors is "adamantly opposed to the concept," and it is "illegal in San Diego for people to buy clean needles without a prescription," KPBS reports. In 2008, the privately-funded exchange program, which has the support of the mayor and the city council, collected more than 183,000 used syringes and handed out about 172,000 new ones (Goldberg, 7/7). This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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