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Misdiagnosis Of Disorders Of Consciousness Still Commonplace
A sixteen-month study of consensus-based diagnosis of patients with disorders of consciousness has shown that 41% of cases of minimally conscious state (MCS) were misdiagnosed as vegetative state (VS), a condition associated with a much lower chance of recovery. Researchers writing in the open access journal BMC Neurology have demonstrated that standardized neurobehavioral assessment is more sensitive than diagnoses determined by clinical consensus.
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AGTC And National Neurovision Research Institute Collaborate, Funding Research In Two Genetic Retinal Diseases
Applied Genetic Technologies Corporation (AGTC), a privately-held, clinical stage biotechnology company developing novel systems to deliver human therapeutics, announces that AGTC has entered into an agreement with the National Neurovision Research Institute (NNRI), the clinical trial support organization for the Foundation Fighting Blindness(FFB), to collaborate in experiments using the AAV delivery system in the treatment of two genetic retinal diseases known to cause blindness at an early age. The research will be coordinated by AGTC and will be conducted at The University of Florida, Oregon Health & Science University, The University of Pennsylvania, and The University of British Columbia.
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ACOG Issues New Guidelines On Fetal Monitoring To Resolve Inconsistencies In Interpretation
The American College of Obstetrics and Gynecology recently published new guidelines on electronic fetal monitoring in an attempt to increase consistency in the way physicians interpret and act on the results, the New York Times reports. Electronic fetal monitoring, which was introduced in the 1970s, is used during labor for more than 85% of the four million infants born alive in the U.S. annually, the Times reports. According to the Times, use of fetal monitors became standard obstetrical practice before it was known if the benefits outweighed the risks. The new guidelines refine the meaning of various readings from fetal monitors and could help doctors make better decisions about whether to intervene during labor.According to experts, the widespread adoption of fetal monitoring has produced both negative and positive consequences, including significant increases in caesarean deliveries and the use of forceps during vaginal deliveries. Monitoring has not been found to reduce the risk of either cerebral palsy or fetal death resulting from inadequate oxygen to the fetal brain, as it was intended to do. Furthermore, lawyers commonly use monitoring results to support malpractice cases that might have little merit, which in turn has driven rising malpractice insurance costs and prompted some obstetricians to stop delivering infants.The new guidelines divide monitor readings into three categories to help doctors interpret readings more consistently. The old guidelines had two categories -- reassuring and non-reassuring -- and it was up to the obstetrician to determine whether a non-reassuring reading required intervention. Under the new guidelines, the first category applies when tracings of the fetal heart rate are normal and no specific action is required. The second category is for indeterminate tracings that require evaluation, continuous surveillance and re-evaluation. Obstetricians treating patients in this category should consider other clinical factors that could affect the fetus and whether the patient could be safely moved to category one, according to Catherine Spong of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, which produced recommendations on which the guidelines are based. The final category is for abnormal tracings that require immediate evaluation and efforts to reverse the abnormal heart rate. The Times reports that more refinements to the guidelines are expected to be released in 2010 (Brody, New York Times, 7/7).
Public Health

Researchers At The University Of Tennessee Health Science Center Begin New Study On Parkinson's Disease

Researchers at the University of Tennessee Health Science Center (UTHSC) are recruiting participants for a national clinical study of medication that could slow the progression of Parkinson"s disease. The study, referred to as "QE3," will examine the effectiveness of the research medication Coenzyme Q10 (CoQ). During the study, investigators will administer high doses of CoQ to participants 30 years of age or older with early stage Parkinson"s disease to reduce the speed of their physical decline. The research is sponsored by the National Institute of Neurological Disorders and Stroke, a division of the National Institutes of Health (NIH), and will be conducted by the Parkinson Study Group, an international council of physicians and researchers experienced in caring for Parkinson"s patients and studying the disease. In Memphis, Ronald Pfeiffer, MD, a neurologist at UT Health Science Center, and a member of the Parkinson Study Group, will lead the local effort of this phase III clinical trial. "Memphians who have been diagnosed with Parkinson"s disease within the last five years and are not receiving treatment for their symptoms may be eligible for the study," said Dr. Pfeiffer. Assigned physicians will examine study volunteers every four months during a 16-month period. Participants will be randomly assigned to receive treatment with either active CoQ (which will also contain vitamin E) or a matching placebo. Investigators at 60 clinical sites in the United States and Canada will enroll about 600 participants with early signs of Parkinson"s disease. Each site will enroll approximately 10 individuals. There is no cost to participate in the study. In Parkinson"s disease, the brain cells that produce a chemical called dopamine are gradually lost, resulting in a decrease in dopamine levels. Without enough dopamine, patients experience symptoms such as tremors, muscle rigidity, balance problems, slow movement and others. Currently, doctors can treat these symptoms with drugs that boost dopamine levels. However, there are no available treatments to reduce the rate of clinical decline. "A medication that could slow the progression of Parkinson disease would be a major breakthrough for patients living with the disease," said Walter Koroshetz, MD, deputy director, NIH National Institute of Neurological Disorders and Stroke. Adults 30 years old and above with early stage Parkinson"s disease who wish to participate in the study should contact Brenda Pfeiffer, UTHSC research nurse coordinator, at (901) 271-5966, or visit the Parkinson Study Group web site at http://www.parkinson-study-group.org. The University of Tennessee Health Science Center


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