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Characterization Of ERG, AR And PTEN Gene Status In Circulating Tumor Cells From Patients With Castration-Resistant Prostate Cancer
UroToday.com - The TMPRSS2-ERG gene fusion occurs in 30-70% of androgen deprivation therapy (ADT) naç¯ve prostate cancers (CaP), but its relevance in castration-resistant prostate cancer (CRPC) is less well defined. The TMPRSS2-ERG gene fusion is androgen driven. In the April 1, 2009 issue of Cancer Research, a group led by Dr. Johann de Bono evaluated patients undergoing treatment with the CYP17 inhibitor abiraterone acetate, which ablates the synthesis of androgens and estrogens that drive the TMPRSS2-ERG gene fusions. They hypothesized that androgen-dependent overexpression of ERG persisted in CRPC and that TMPRSS2-ERG tumors represented a subgroup of CaP that remained sensitive to abiraterone acetate. They hypothesized that two mechanisms of resistance to abiraterone acetate were gain of AR and loss of PTEN that could result in constitutive phosphorylation of AR, leading to ligand-independent activation.
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Important Genetic Variation Connected To Malaria Resistance
Researchers at the Duke University Institute for Genome Sciences & Policy have found that variation in the same gene in humans and baboons produces the same kind of disease resistance. The findings were published in the June 24 online edition of the journal Nature.
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Physicians Support New Immunizations, Urge Children To Get Vaccinations
New rules require more vaccinations before a child can start kindergarten or seventh grade this fall. The physicians of the Texas Medical Association (TMA) are urging parents to get their child"s shots now before school starts.
Oncology

Opinion: Governments Must Take 'Concrete Action' To Reduce Maternal Mortality, Morbidity

With the U.N. Human Rights Council"s June session coming up, governments have a "chance to prove that they value women"s lives by taking concrete action" to recognize "preventable maternal death as a violation of women"s rights," Mary Robinson and Alicia Yamin, advisory council members of the International Initiative on Maternal Mortality and Human Rights, write in a Boston Globe opinion piece. In this "critical year" leading up to the U.N. Millennium Development Goals (MDGs) review in 2010, the council has an "historic opportunity in its June session to recognize the need to incorporate human rights into programs and policies designed to combat maternal deaths and encourage international cooperation and assistance in this area," Robinson and Yamin write. Although "we know what is needed to save women"s lives" women are still dying or "left with lifelong, debilitating complications. Moreover, when mothers die, children are at greater risk of dropping out of school, becoming malnourished, and simply not surviving. Not only is maternal mortality and morbidity a global health emergency, but it triggers and aggravates cycles of poverty that cause generations of suffering and despair," Robinson and Yamin write, adding that "saving women"s lives" would cost an estimated additional "$6 billion a year to be on track to achieve" the U.N. MDGs. They write that "poor governments" will not "be blamed for not doing what they cannot do," but asserting that these "preventable deaths are an issue of human rights" highlights the "profound injustice of disparities in maternal deaths" and makes it "more urgent that donor states honor their funding commitments." Robinson and Yamin conclude that the U.S., as a new member of the Human Rights Council, "has the chance to lead the way in promoting a woman"s right to go through pregnancy and childbirth in safety and, just as important, to back up that assertion with adequate funding commitments" (Robinson/Yamin, Boston Globe, 6/4). This information was reprinted from globalhealth.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Global Health Policy Report, search the archives and sign up for email delivery at globalhealth.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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