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Characterization Of ERG, AR And PTEN Gene Status In Circulating Tumor Cells From Patients With Castration-Resistant Prostate Cancer
UroToday.com - The TMPRSS2-ERG gene fusion occurs in 30-70% of androgen deprivation therapy (ADT) naç¯ve prostate cancers (CaP), but its relevance in castration-resistant prostate cancer (CRPC) is less well defined. The TMPRSS2-ERG gene fusion is androgen driven. In the April 1, 2009 issue of Cancer Research, a group led by Dr. Johann de Bono evaluated patients undergoing treatment with the CYP17 inhibitor abiraterone acetate, which ablates the synthesis of androgens and estrogens that drive the TMPRSS2-ERG gene fusions. They hypothesized that androgen-dependent overexpression of ERG persisted in CRPC and that TMPRSS2-ERG tumors represented a subgroup of CaP that remained sensitive to abiraterone acetate. They hypothesized that two mechanisms of resistance to abiraterone acetate were gain of AR and loss of PTEN that could result in constitutive phosphorylation of AR, leading to ligand-independent activation.
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Positive Results For First Disease-Modifying Compound Targeting Protein Misfolding
Discoveries by Scripps Research Institute scientists have led to a promising new drug candidate - the first in its class - for patients with a genetic protein-misfolding disease. In results announced by the biopharmaceutical firm FoldRx Pharmaceuticals, Inc., the new drug tafamidis significantly halts disease progression for patients with a disease called Transthyretin (TTR) amyloid polyneuropathy (ATTR-PN).
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Conference: Discovery Partnerships: Academia & Industrial Interactions
Opal Events is proud to present our next exciting conference Drug Discovery Partnerships: Academia & Industrial Interactions , to be held at the Hyatt Regency in Boston on October 28-30, 2009.
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Obama Busy 'Selling The Greater Good' On Health Reform

President Barack Obama, in comments about health reform, has acknowledged what most Americans already know, that "(w)hat"s good for the health care system as a whole often looks very different when it"s their own health at stake, or the health of someone in their family," CQPolitics reports. "But in acknowledging that fact, Obama highlighted what is perhaps his biggest challenge in maintaining support for remaking the health care system. He has to make sure Americans don"t think they will personally lose out in an overhaul of the way medical services are delivered -through higher costs to themselves, lower quality of care or simple inability to get the care they"re convinced they need." What reform means to Americans personally is a driving factor that many lawmakers are ignoring, CQ Politics reports. "The only player who can truly close the sale on the health care overhaul is Obama himself. For that to happen, he"ll need to excel both as the nation"s educator in chief and as its salesman in chief." ""There is one central challenge in this debate, and all of the other challenges stem from it. Right now, the middle class cannot answer the question, "What"s in it for me?"" said Jim Kessler, vice president for policy at Third Way, a messaging and policy group for centrist Democrats. "That is the No. 1 public relations challenge right now. There is no No. 2."" "Indeed, administration officials argue that the biggest cause of public anxiety right now is not the potential costs of an overhaul, but the escalating personal costs they face with the current health care system: the rising premiums, co-payments and deductibles; the lost wages; the businesses that can"t afford to hire enough workers. "The goal of health care reform, above all, is to make sure that your health care costs go down," said Linda Douglass, communications director for the White House Office of Health Reform. "But in the coming weeks, with actual legislative details to look at and financing decisions to be made to pay for the emerging cost estimates, the public will begin to hear more about what kind of personal costs they might face. They"ll hear about possible taxes on their benefits and other ways they might have to pay more, at least in the short term, until the changes begin to save money. And they"ll hear from Republicans about the prospect of rationed health care." Public care is moveable, it"s not that Americans are afraid of reform, Kaiser Family Foundation President Drew Altman told CQ Politics. "Still, lawmakers are keenly aware of the public"s views, which is why they"re watching Obama"s efforts - through frequent speeches and town hall forums - to assure the majority of Americans with health insurance that they won"t lose out because of an overhaul. "The outcome is going to be determined by the people who already have coverage," said Democratic Sen. Evan Bayh of Indiana." "Leading the public in a discussion of what they can live without, even if it"s necessary to save the health care system, may be more than any political leader wants to take on - even one with Obama"s communication skills. But there really isn"t anyone else who can do it on a national level" (Nather, 7/8). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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