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GlaxoSmithKline And Genmab Announce Top-line Results For Ofatumumab In Rheumatoid Arthritis
GlaxoSmithKline (GSK) and Genmab A/S (OMX: GEN) announced preliminary top-line results from a Phase III study of ofatumumab administered intravenously for the treatment of rheumatoid arthritis (RA) in patients who had an inadequate response to methotrexate. The study met the primary endpoint, ACR20 at 24 weeks, which indicates a 20 percent or greater improvement in the number of swollen and tender joints, as well as improvements in other disease-activity measures.
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Misdiagnosis Of Disorders Of Consciousness Still Commonplace
A sixteen-month study of consensus-based diagnosis of patients with disorders of consciousness has shown that 41% of cases of minimally conscious state (MCS) were misdiagnosed as vegetative state (VS), a condition associated with a much lower chance of recovery. Researchers writing in the open access journal BMC Neurology have demonstrated that standardized neurobehavioral assessment is more sensitive than diagnoses determined by clinical consensus.
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Development of Compact Gamma Camera For Imaging Of Prostate Cancer
The U.S. Department of Energy"s Brookhaven National Laboratory and Hybridyne Imaging Technologies, Inc., of Toronto, Canada, have won a 2009 R&D 100 Award for developing a compact gamma camera for high-resolution imaging of prostate cancer. The camera system, called ProxiScan, is a nuclear medical instrument that can localize cancer tissue in the prostate gland in detail at an early stage, which is important for the successful diagnosis and early treatment of the potentially deadly disease.
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New Malaria Agent Found In Chimpanzees Close To That Commonly Observed In Humans

Researchers based in Gabon and France report the discovery of a new malaria agent infecting chimpanzees in Central Africa. This new species, named Plasmodium gaboni, is a close relative of the most virulent human agent P. falciparum; it is described in an article published May 29 in the open-access journal PLoS Pathogens. P. falciparum is the major human malaria agent responsible for one to three million deaths annually. In 2002, the publication of the genome of P. falciparum generated new hopes in the fight against this deadly disease, by the opportunities it offered to discover new drug targets. However, the lack of known related genomes has limited the development of comparative genomics according to the study"s researchers from Centre International de Recherches Mē©dicales de Franceville, Centre National de la Recherche Scientifique, and l"Institut de Recherche pour le Dē©veloppement. To investigate the diversity of Plasmodium parasites circulating in chimpanzees in Africa, the team collected blood from 19 wild-borne animals kept as pets by villagers in Gabon. Two were found infected by a Plasmodium parasite. The sequencing of the parasite"s whole mitochondrial genome revealed that it belonged to a previously undescribed species of Plasmodium, closely related to P. falciparum. Sequencing of the nuclear genome of this new agent should further the understanding of genomic adaptations of P. falciparum to humans and thus help discover new potential drug targets. The development of comparative genomics to further understanding of P. falciparum has been hindered by a lack of knowledge of closely related species" genomes. Only one species, P. reichenowi, infecting chimpanzees, was previously known as a sister lineage of P. falciparum. Additional information on related species has thus been needed, making the discovery of P. gaboni an important step forward in exploring a possible relationship for malaria between chimpanzees and humans. CITATION: "A New Malaria Agent in African Hominids." Ollomo B, Durand P, Prugnolle F, Douzery E, Arnathau C, et al. (2009) PLoS Pathog 5(5): e1000446. doi:10.1371/journal.ppat.1000446 PLoS Pathogens


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