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Obama Readies Stronger Hand On Health Reform, Plans Meetings With Players
The next two weeks of a health reform fight may prove pivotal for President Barack Obama"s image and his ability to use his popularity to get things done, The Washington Post reports.
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Fragility Fractures And Osteoporosis
Low energy fractures of the proximal humerus indicate osteoporosis and it is important to direct treatment in order to prevent further fractures. Therefore, in this study the authors collected data from 79 patients with fractures of the proximal humerus in order to determine if current guidelines on measurement of bone mineral density at the hip and lumbar spine were adequate to stratify the risk and to guide the treatment of osteoporosis.
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Virus-Gene Therapy Combination Being Tested Against Melanoma
Researchers at the Moores UCSD Cancer Center are injecting a modified herpes virus into melanoma tumors, hoping to kill the cancer cells while also bolstering the body"s immune defenses against the disease.
Medical Devices

Key Data Related To Plexxikon's Lead Oncology Program PLX4032 To Be Presented At ASCO 2009 Annual Meeting

Plexxikon Inc., announced that key data related to PLX4032 and its development, will be presented in three separate presentations at the American Society of Clinical Oncology (ASCO) 2009 Annual Meeting taking place May 29 through June 2, 2009 in Orlando, Florida. The presentation information is as follows: - Abstract #9021: "PLX4032, a highly selective BRAFV600E kinase inhibitor: correlation of activity with pharmacokinetic and pharmacodynamic parameters in a Phase 1 trial" - Poster to be presented on May 30, 2009, 8:00 a.m. - 12:00 p.m. EDT by Igor Puzanov, M.D., assistant professor of medicine, Vanderbilt University Medical Center, in the melanoma poster discussion session - Abstract #11003: "Selecting subjects for a therapeutic target in colorectal cancer (CRC): Using a clinical database to enrich for patients harboring the BRAFV600E mutation" - Oral presentation to be made on June 1, 2009, 9:30 a.m. EDT by Jeanne Tie from the Ludwig Institute for Cancer Research in the "Tumor Biology and Human Genetics" session - Abstract #9000 : "Phase 1 study of PLX4032: Proof-of-concept for V600E BRAF mutation as a therapeutic target in human cancer" - Oral presentation to be made on June 1, 2009, 4:30 p.m. to 6:00 p.m. EDT by Keith T. Flaherty, assistant professor, University of Pennsylvania Abramson Cancer Center, in the "Molecular Phenotype of Melanoma Subtypes and Patient-Specific Therapy" session. Link to video clip of Dr. Flaherty. About PLX4032 (R7204)-A Personalized Medicine for Cancer Treatment PLX4032 is a novel, oral small molecule for the treatment of melanoma and other cancers harboring the V600E mutation of the BRAF kinase gene. This defect is present in approximately 60 percent of melanoma skin cancers, and occurs in about eight percent of all solid tumors, including melanoma, colorectal, thyroid and other cancers. Preclinical data suggest that Plexxikon"s novel anti-cancer compound selectively targets and regresses tumors which contain this cancer-causing mutation. In contrast to many other kinase inhibitors available, PLX4032 is highly selective for its primary target, and does not have significant activity on other kinase targets. Plexxikon


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