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Bionovo Presents Positive Results From Phase 1B Trial Of Bezielle For Metastatic Breast Cancer
Bionovo, Inc. (Nasdaq: BNVI) announced positive results from the Phase 1B clinical trial of Bezielle (formerly BZL101), their lead drug candidate for advanced breast cancer. In the trial, Bezielle showed an excellent safety and tolerability profile, and also showed promising indications of efficacy in a difficult-to-treat population.
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Both Phase III Pivotal Trials Begin Enrollment In May 2009; Reinforces Lilly's Commitment To Alzheimer's Disease And Biotech Product Research
Eli Lilly and Company (NYSE: LLY) announced it will begin enrolling
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Possible Treatment For Spinal Muscular Atrophy
Spinal Muscular Atrophy is the second-leading cause of infant mortality in the world.
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Human Gastric Cancer: A Potent And Selective Anti-Tumor Agent

A research article published in the World Journal of Gastroenterology refers. The research team led by Professor Yan Li from Shengjing Hospital of China Medical University studied the growth inhibitory effects of Alisol B acetat and determined its mechanism of antitumor activity in human gastric cancer cell line SGC7901. Professor Li and his colleagues found that Alisol B acetat could inhibit the proliferation of SGC7901 cell in a time and dose dependent manner. Among the various phases of cell cycle, the percentage of cells in S phase was significantly decreased, while the percentage of cells in G1 phase was increased. Flow cytometry assay also showed Alisol B acetate had positive effect on apoptosis. Typical apoptotic morphology such as condensation and fragmentation of nuclei and formation of apoptotic bodies could be observed through electron microscope and phase-contrast microscope. Further investigating the molecular mechanism behind Alisol B acetat -induced apoptosis, cells treated with Alisol B acetat underwent a rapid loss of mitochondrial transmembrane potential, activition of caspase-3, -9, upregulation of Apaf-1 and Bax, and inhibition of the PI3K/Akt in a time-dependent manner. The researches domenstrated for the first time that Alisol B acetate induced human gastric cancer apoptosis through regulation of mitochondrial and PI3K/AKT signaling pathways Their research results indicate that Alisol B acetate might be used to treat gastric cancer , one of the most common cancers worldwide. By knowing the mechanism of action of Alisol B acetate, it may provide a new therapeutic option, as a potential anticancer agent, in the treatment of gastric cancer. Reference: Xu YH, Zhao LJ, Li Y. Alisol B acetate induces apoptosis of SGC7901 cells via mitochondrial and phosphatidylinositol 3-kinases/Akt signaling pathways. World J Gastroenterol 2009; 15(23): 2870-2877 http://www.wjgnet.com/1007-9327/15/2870.asp Correspondence to: Yan Li, Professor, Department of Digestive Diseases, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province,China. Lin Tian World Journal of Gastroenterology


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