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AICR Statement: Hot Dogs And Cancer Risk
The American Institute for Cancer Research (AICR) and our landmark 2007 AICR/WCRF expert report, Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective, have been drawn into a controversy over the link between processed meat and cancer risk.
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Study First To Evaluate Prevalence, Impact Of Off Label Chemotherapy In Breast Cancer
At some point during their care, more than one-third of metastatic breast cancer patients receive chemotherapy off label, the legal use of FDA-approved drugs in a different indication than for which they were approved, according to researchers at The University of Texas M. D. Anderson Cancer Center.
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Tiller's Patients, Not Critics, Should Be Ones To 'Define His Memory,' Opinion Piece Says
In a "portrayal that defied logic," George Tiller -- the Kansas abortion provider who was murdered last month -- has been depicted "on Web sites, TV and radio talk shows and in legislative hearings as the reckless "abortionist," willing to euthanize babies close to birth just so the mother could fit into a prom dress or attend a rock concert," Barbara Shelly, a member of the Kansas City Star editorial board, writes in a Star opinion piece. She asks, "Would someone in the third trimester of pregnancy travel to the heart of Kansas and pay a $6,000 fee just to fit into a size six party dress?" Shelly adds that the "overwhelming majority of the 250 to 300 women a year" that sought abortions from Tiller in the second and third trimesters had planned their pregnancies. She profiles a Missouri college professor, pregnant with twins, who traveled to Tiller"s clinic with her husband to obtain an abortion after an amniocentesis revealed that neither fetus would survive and that she faced potentially life-threatening complications if the pregnancy continued. Shelly writes that the woman and others like her went to Tiller "heartbroken and afraid, carrying fetuses with malfunctioning kidneys, missing organs and syndromes certain to cause death in the womb or soon after birth." A smaller number were survivors of rape and incest, including young girls, according to Shelly. The "prom queen who talked her way into a late-term abortion" is a "creation of Tiller"s enemies," Shelly writes, concluding that the "real people" affected by his death are the "thousands who wrote the notes that now serve as a memorial wall to a fallen physician. They are the ones who should define his memory" (Shelly, Kansas City Star, 6/9).
Public Health

Fragility Fractures And Osteoporosis

Low energy fractures of the proximal humerus indicate osteoporosis and it is important to direct treatment in order to prevent further fractures. Therefore, in this study the authors collected data from 79 patients with fractures of the proximal humerus in order to determine if current guidelines on measurement of bone mineral density at the hip and lumbar spine were adequate to stratify the risk and to guide the treatment of osteoporosis. The World Health Organisation defines osteoporosis by comparing the bone mineral density with that of a gender-matched, healthy young adult reference population. A T-score in women of less than -2.5 at any one of three skeletal sites, the femur, the lumbar spine or the distal radius is the WHO "gold standard" for diagnosing osteoporosis. However, the most common clinical method for assessing the BMD is dual-energy x-ray absorbtiometry of the central skeleton taken at the hip and lumbar spine. Therefore, the authors decided to analyse the sensitivity of these sites and the distal radius in diagnosing osteoporosis in accordance with WHO criteria. The results show that "there is a wide variation in the BMD when measured at different skeletal sites" and that when considering injuries to the upper limb, the BMD measured at the distal radius may represent the risk of osteoporotic humeral fractures better than that measured at the axial skeleton or lower limbs. This is because the distal radius has a large proportion of cancellous bone which is affected to a greater extent by age-related changes in the BMD. Therefore, the authors conclude that "measurement of the BMD at the hip and lumbar spine, if used alone, may underestimate the risk of osteoporosis in the upper limb" and that measurement of the BMD at the radius should not be omitted when osteoporosis is being investigated. Read the full text article. The Journal of Bone and Joint Surgery


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