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In A Chemical Library, Yale Researchers Find Keys To Cell Movement
Rummaging through a biotechnology company"s chemical closet, Yale University researchers found two molecules that will allow scientists to better study how cells move. The study in the journal Nature, published online Aug. 2, describes how two small molecules discovered by Cytokinetics Inc. block the action of a key complex that directs the assembly of actin filaments, which produce the force to help cells move. The target of these inhibitors is the Arp2/3 complex, a cellular component so vital that cells die without it. This dependence has made it challenging to learn exactly which cellular processes depend upon the complex.
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Golden Rice An Effective Of Vitamin A
The beta-carotene in so-called "Golden Rice" converts to vitamin A in humans, according to researchers at Baylor College of Medicine and Tufts University in an article that appears in the current issue of the American Journal of Clinical Nutrition.
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Lives May Be Saved By Osteoporosis Drug's Strengthening Of The Immune System
An osteoporosis drug proven to save lives after hip fractures may do so by strengthening the body"s immune system, according to geriatrics researchers at Duke University Medical Center.
Oncology

Discovery Of Association Between Obstructive Sleep Apnea And Weight Gain

According to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, a link exists between the severity of obstructive sleep apnea (OSA) and weight gain. Results indicate that people with an apnea-hypopnea index (AHI), the average of the combined episodes of apnea and hypopnea that occur per hour of sleep, of over 15 had an increase in body mass index (BMI) of 0.52 kg/m2 compared to those with an AHI between 5 and 15, who saw an increase of 0.22 kg/m2. According to lead author Mark Brown, MD, Department of Psychiatry at the University of Arizona College of Medicine in Tucson, people suffering from more severe OSA may be more likely to gain more weight than those with less severe OSA over time. "OSA is a disorder characterized by decreases or cessation of breathing during sleep. Obesity is a known risk factor for the disorder; however, it is hypothesized that the effects of OSA itself may predispose patients to weight gain," said Brown. The study included data from 3,001 men and women from the Sleep Heart Health Study (SHHS) with an average age of 62.19. Of the sample, 55.2 percent of participants were female and 76.1 percent were Caucasian. Participants were classified as having no (AHI of less than 5), moderate (AHI between 5 and 15), and severe OSA (AHI of over 15). Weight and polysomnograph information were collected. Linear regression was used to examine the association between AHI groups and the change in BMI over approximately five years. The final model was adjusted for age, gender, race, initial BMI and change in AHI over 5 years. Abstract Title: Sleep-Disorded Breathing and Weight Gain: The Sleep Heart Health Study. Presentation Date: Thursday, June 11 Category: Sleep Disorders -Breathing Abstract ID: 0515 Kelly Wagner American Academy of Sleep Medicine


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