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Ethics Review Of Research In The Context Of Humanitarian Relief Work
Two articles published this week in the open-access journal PLoS Medicine
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Addex Partner Starts First-Ever Clinical Trial Of An MGluR Positive Allosteric Modulator
Allosteric modulation company Addex Pharmaceuticals (SWISS: ADXN) announced today that its partner Ortho-McNeil- Janssen Pharmaceuticals Inc. (OMP) has started Phase I testing of ADX71149, a metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulator (PAM). This product, which has potential to treat schizophrenia, anxiety, depression and other CNS disorders, is the first PAM of any mGluR subtype to enter clinical trials. Targeting mGluR2 with a PAM is a novel approach that may offer advantages over classical drug approaches. In reaching this milestone, Addex received a EUR 1 million payment from OMP and remains eligible for additional development milestones and royalties.
News of the day
Deworming Drug Could Help Reduce Spread Of HIV In Africa, Study Finds
Providing girls in rural Africa with a deworming drug could help reduce the spread of HIV, according to a study recently published in PLoS Neglected Tropical Diseases, the New York Times reports. The drug, called praziquantel, costs about 32 cents per pediatric dose and prevents schistosomiasis, a worm disease that starts as a urinary tract infection. If untreated, schistosomiasis can lead to female genital sores that can facilitate HIV infection. Because the drug can kill the worms but cannot cure genital sores, girls should be protected before they reach sexual maturity, according to the Times. "For this relatively small investment, the reproductive health of young women would be improved," the authors from the Sabin Vaccine Institute, Imperial College London and Oslo University wrote, adding that "there is a reasonable chance that HIV/AIDS transmission can be reduced." There are about 207 million schistosomiasis cases worldwide, 90% of which occur in Africa, where humans are exposed usually through snail-infested water. According to a pilot program conducted in Burkina Faso, all 70 million cases among young children in Africa could be treated for $22 million, and repeating universal treatment every two years for 10 years would cost $112 million (McNeil, New York Times, 5/26).
Nutrition

Digital Mammography And Clinical Review Display Units Energising The European Markets For Medical Imaging Display Monitors, Finds Frost & Sullivan

Diagnostic display monitors have experienced slow growth in 2007 due to picture archiving and communication system (PACS) installations across radiology departments of European hospitals having reached saturation. However, favourable regulations mandating the sales of 5MP displays for digital mammography have ensured high-volume sales in several European countries. The increasing demand for clinical review display monitors from private practitioners has also ensured very high growth rates for medical imaging display monitors. New analysis from Frost & Sullivan (http://www.medicalimaging.frost.com), European Medical Imaging Display Monitors Market, finds that the market earned revenues of $207.2 million in 2007 and estimates this to reach $520.4 million in 2014. The following segments are covered in this research: acquisition display, diagnostic display, surgical display, clinical review display and mammography display. "A favourable reimbursement scenario combined with an improving regulatory environment for digital mammography has resulted in the large volume sales of 5MP mammography display monitors," notes Frost & Sullivan Research Analyst Shriram Shanmugham. "PACS installations are set to expand beyond their conventional deployment in radiology departments with the market for diagnostic display monitors poised to grow steadily in the cardiology and surgical departments of European hospitals." The mounting demand to include colour images in the daily workflow of radiologists has supported sustained market growth in the past two years. Display manufacturers will also benefit from the steady increase in PACS installations across cardiology departments. The sales of acquisition displays suffered in 2007 due to most imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) reaching maturity. Market growth has also been adversely affected by the saturation in radiology PACS installations in European hospitals. The lack of stringent standards and mandates will affect volume sales of clinical review display monitors in the coming years. "A cost-cutting spree amongst European hospitals has directly affected the sale of imaging equipment, hampering the sales of acquisition display monitors attached to these systems," remarks Shanmugham. "Revenue channels from PACS installations have also started closing down owing to saturation of PACS in large and medium-size hospitals. With hospitals hesitating to invest in high definition displays for surgical suites, market penetration of surgical displays is projected to be low in the near future." Vendors should target small and medium-sized hospitals where PACS installations are yet to be made in order to ensure sustained revenue generation from slow growing market segments such as diagnostic displays. They also need to establish efficient distribution channels to be able to reach private practitioners and boost volume sales of clinical review display monitors. "Display manufacturers will have to come up with competitive promotional offers for surgical display monitors to encourage higher adoption rates," advises Shanmugham. "Also, as hospitals reduce their outlay on display monitors and other large imaging modalities, vendors need to develop innovative post processing and 3D image reconstruction software. This will enable sustained revenue generation." European Medical Imaging Display Monitors Market is part of the Medical Imaging Growth Partnership Service programme, which also includes research in the following markets: Eastern European Ultrasound Market, European Medical Imaging Equipment Market for Cardiology Applications and Eastern European Medical Imaging Modalities. All research included in subscriptions provide detailed market opportunities and industry trends that have been evaluated following extensive interviews with market participants. Frost & Sullivan


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