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Exposure To Audible Television Has Implications For Language Acquisition And Brain Development
In a new study, young children and their adult caregivers uttered fewer vocalizations, used fewer words and engaged in fewer conversations when in the presence of audible television. The population-based study is the first of its kind completed in the home environment, guided by lead researcher Dimitri A. Christakis, MD, MPH, director of the Center for Child Health, Behavior and Development at Seattle Children"s Research Institute and professor of pediatrics at the University of Washington School of Medicine. "Audible Television and Decreased Adult Words, Infant Vocalizations, and Conversational Turns" was published in the June 2009 issue of Archives of Pediatrics & Adolescent Medicine.
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Senate Finance Committee Under Pressure To Produce Health Bill
President Obama told Sen. Max Baucus that he wants a Senate Finance Committee health overhaul bill by the end of the week, The Associated Press reports. "These officials said Obama made his wishes known directly to Baucus, D-Mont., at a White House meeting Monday attended by administration officials and senior Democratic lawmakers."
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House Passes Spending Bill; Amendment To Block Removal Of Needle Exchange Funding Ban Defeated
The House on Friday passed a $730.5 billion bill (HR 3293) "to fund health, education and labor programs in fiscal 2010 after narrowly defeating an attempt to strip language that would lift the ban on federal needle exchange programs," in the U.S., CQ Today reports (Wolfe, 7/24). Lawmakers voted 211-218 to reject an amendment by Mark Souder (R-Ind.) that sought to keep the ban in place, the AP/Lewiston Sun Journal reports (Taylor, 7/25). The bill that passed includes a restriction against using federal funds for needle exchanges within 1,000 feet of day care centers, schools, parks, playgrounds, pools and youth centers, the Washington Post reports.
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Brain Neural Circuit Formation Requires Identification Of A Key Molecular Pathway

The research group of Dr. Frçİdçİric Charron, a researcher at the Institut de recherches cliniques de Montrçİal (IRCM), has made a discovery which could help treat spinal cord injuries and neurodegenerative diseases. This new finding has been published in the current issue of the prestigious scientific journal Neuron. Patricia T. Yam, Sçİbastien D. Langlois and Steves Morin, all at the IRCM, are listed as co-authors. The brain is composed of billions of interconnected neurons. To correctly form neuronal circuits, the developing axons (a long extension of a neuron) require attractive and repulsive molecules to lead them to their appropriate targets. One such molecule is Sonic Hedgehog (Shh). Five years ago, as a postdoctoral fellow in the laboratory of Dr. Marc Tessier-Lavigne at Stanford University, Frçİdçİric Charron discovered that Shh acted as an axonal attractant for brain and spinal cord neurons. "How exactly Shh elicited this effect has remained unknown so far," pointed out Dr. Charron. "The molecular pathway my team discovered provides part of an answer." Their recent work showed that Shh exerts its attractive effect through a group of molecules called Src family kinases (SFKs) that, until now, were not known to be linked to Shh function. Remarkably, these novel Shh effector molecules are absolutely required for the ability of Shh to guide axons. Connecting axons with an appropriate set of targets is very complex. Inappropriate wiring or damage to these neuronal connections leads to severe abnormalities of the nervous system. "Knowing the effectors of axon guidance molecules such as Shh", adds Dr. Charron, "helps us to understand the molecular mechanisms by which axons reach their target. It paves the way to new therapies to treat spinal cord injuries, neurodevelopmental disorders, and neurodegenerative diseases." This new discovery was made possible through the invention of a novel technique to control and observe the behavior of axons in response to guidance molecules. A patent application for this technique has been filed recently. This invention is expected to speed up the discovery of drugs that control axon pathfinding. "Dr. Charron is one of the country"s leading newly arrived neuroscientists. This research has important long-term implications for the repair of spinal cord injury: if we knew all of the molecules required to guide axons correctly during spinal cord healing, we would probably know how to heal spinal cord injuries," says Dr. Rod McInnes, Scientific Director of the Canadian Institutes of Health Research Institute of Genetics. "This is beautiful research that adds another major brick to our building a complete understanding of how the spinal cord is made, and how injury of it can be treated." This work was supported by grants from the Canadian Institutes of Health Research (CIHR), the Canadian Foundation for Innovation (CFI), the McGill Program in Neuroengineering, the Fonds de recherche en santçİ du Quçİbec (FRSQ) and the Peter Lougheed Medical Research Foundation. Olivier Lagueux Institut de recherches cliniques de Montreal


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